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钱伟强  作物表观遗传研究组客座研究员


邮箱:wqqian@pku.edu.cn

研究方向:植物表观遗传与逆境响应



个人简介:

教育经历:

1998.9-2002.7 北京师范大学,生物学,理学学士

2002.9-2007.7 中国科学院遗传与发育生物学研究所,遗传学,理学博士

2006.11-2007.5 加拿大女皇大学,访问学者

工作经历:

2007.7-2009.4 美国康奈尔大学,博士后

2009.5-2010.12 美国加州大学河滨分校,博士后

2011.1-2011.12 美国普渡大学,博士后

2012.1-2013.6  中国科学院上海植物逆境生物学研究中心,青年研究员

2013.7-2021.7  北京大学生命科学院,北大-清华生命联合中心,研究员

2021.7 – 至今 北京大学现代农学院,北京大学现代农业研究院,研究员

主要荣誉:

国家自然基金委“优秀青年基金”获得者

研究工作:

以拟南芥和水稻等为模式植物,综合运用遗传学、生物化学和细胞生物学的方法,对植物体内表观遗传的分子机制和生物学功能进行深入的研究。主要研究方向包括:1、植物基因组DNA主动去甲基化的分子机制和生物学功能;2、植物基因沉默的表观遗传学机制和生物学功能;3、植物响应周围环境的表观遗传机制。

研究成果:

近年来在植物表观遗传领域取了一系列基础研究成果:鉴定了一个调控去甲基化酶ROS1招募的IDM1蛋白复合体,阐明了ROS1招募的分子机制解析了DNA主动去甲基化的酶学机制,揭示了DNA主动去甲基化在植物维管分化过程中的重要功能;解析了植物响应逆境的表观遗传机制。在Science Advances、Nature Communications、Nature Plants、Plant Cell、Molecular Plant等国际主流刊物上发表了SCI论文40多篇,其中通讯作者15篇(包括2篇Science Advances、1篇Nature Plants、1篇Nature Communications、1篇Cell Host & Microbe、2篇Plant Cell、1篇Molecular Plant),第一作者或共同第一作者7篇(包括1篇Science、2篇Molecular Cell和1篇Plant Cell)。

代表性论文:(*共同第一作者, # 通讯作者)

    1. Wang Y. *, Liu Y. *, Qu S., Liang W., Sun L., Ci D., Ren Z., Fan L-M., and Qian W. # (2022) Nitrogen starvation induces genome-wide activation of transposable elements in Arabidopsis. J. Integr. Plant Biol. doi: 10.1111/jipb.13376

     2. Cao Y., Wang J., Wu S., Yin X., Shu J., Dai X., Liu Y., Sun L., Zhu D., Deng X.W., Ye K., and Qian W.# (2022) The small nucleolar RNA SnoR28 regulates plant growth and development by directing rRNA maturation. Plant Cell, 34, 4173-4190.

     3. Liu N.*, Xu Y.*, Li Q., Cao Y., Yang D., Liu S, Wang X, Mi Y., Liu Y, Ding C., Liu Y., Tuan YW., Gao G., Chen J.#Qian W.#, and Zhang X.# (2022) A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell Host Microbe, 30, 1124-1138.

     4. Tong J.*, Ren Z.*, Sun L.*, Zhou S., Yuan W., Hui Y., Ci D., Wang W., Fan L-M., Wu Z., and Qian W. # (2022) ALBA proteins confer thermotolerance through stabilizing HSF mRNAs in cytoplasmic granules. Nat. Plants, 8, 778-791.

     5. Li J.*, Liang W.*, Liu Y., Ren Z., Ci D., Chang J., and Qian W.# (2022) The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates. Plant Cell, 34, 852-866.

     6. Liang W.*, Li J.*, Sun L.*, Liu Y., Lan Z., and Qian W.# (2022) Deciphering the synergistic and redundant roles of CG and non-CG DNA methylation in plant development and TE silencing. New Phytol. 233, 722-737.

     7. Lin W.*, Sun L.*, Huang R., Liang W., Liu X., He H., Fukuda H., He X.Q.#, and Qian W.# (2020) Active DNA demethylation regulates tracheary element differentiation in ArabidopsisSci. Adv. 6, eaaz963.

     8. Sun L.*, Jing Y.*, Liu X.*, Li Q.*, Xue Z., Cheng Z., Wang D., He H.#, and Qian W.# (2020) Heat stress-induced transposon activation correlates with 3D chromatin organization rearrangement in ArabidopsisNat. Commun. 11(1):1886. doi: 10.1038/s41467-020-15809-5.

     9. Yuan, W.*, Zhou, J.*, Tong, J.*, Zhuo, W., Wang, L., Li, Y., Sun, Q.#, and Qian, W.# (2019). ALBA protein complex reads genic R-loops to maintain genome stability in ArabidopsisSci. Adv. 5, eaav9040.

     10. Wang, X., Chen, X., Sun, L., and Qian, W. # (2019). Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in ArabidopsisPLoS Genet. 15, e1008094.

     11. Li, J.*, Liang, W.*, Li, Y., and Qian, W. # (2018). APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE play overlapping roles in the maintenance of epigenome and genome stability. Plant Cell 30, 1954-1970.

     12. Li, Y.*, Kumar, S.*, and Qian, W.# (2018). Active DNA demethylation: mechanism and role in plant development. Plant Cell Rep. 37, 77-85.

     13. Jing, Y. *, Sun, H. *, Yuan, W., Wang, Y., Li, Q., Liu, Y., Li, Y., and Qian, W. # (2016). SUVH2 and SUVH9 couple two essential steps for transcriptional gene silencing in ArabidopsisMol. Plant 9, 1156-1167.

     14. Wang, X.*, Li, Q.*, Yuan, W., Cao, Z., Qi, B., Kumar, S., Li, Y., and Qian, W. # (2016). The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation. Sci. Rep. 6, 26443.

     15. Li, Q.*, Wang, X.*, Sun, H., Zeng, J., Cao, Z., Li, Y., and Qian, W. # (2015). Regulation of active DNA demethylation by a Methyl-CpG-Binding domain protein in Arabidopsis thalianaPLoS Genet. 11, e1005210.

     16. Qian, W.*, Miki, D.*, Lei, M.*, Zhu, X., Zhang, H., Liu, Y., Li, Y., Lang, Z., Wang, J., Tang, K., Liu. R., and Zhu. J.K. (2014). Regulation of active DNA demethylation by an α-crystallin domain protein in ArabidopsisMol. Cell 55, 361-371.

     17. Qian, W.*, Miki, D.*, Zhang, H., Liu, Y., Zhang, X., Tang, K., Kan, Y., La, H., Li, X., Li, S., Zhu. X., Shi. X., Zhang. K., Pontes. O., Chen. X., Liu. R., Gong. Z., and Zhu. J.K. (2012). A histone acetyltransferase regulates active DNA demethylation in ArabidopsisScience 336, 1445-1448.