郭立  园艺作物基因组学与合成生物学实验室主任


邮箱:li.guo@pku-iaas.edu.cn

电话:0536-6030818

研究方向:作物基因组学与生物信息学,植物与微生物互作,天然产物生物合成与调控

实验室主页:http://www.guo-lab.site



个人简介:
2002年08月-2006年06月,西北农林科技大学,植物保护学,学士(BA)

2006年08月-2012年02月,美国宾夕法尼亚州立大学 (Penn State University) 植物病理学,博士(Ph.D.)
2012年03月-2016年08月,美国马萨诸塞大学 (UMASS) 生物化学与分子生物学系,博士后(Postdoc)
2016年09月-2020年06月,西安交通大学,电子与信息学院,副教授 (Associate Professor)
2020年07月-2021年09月,西安交通大学,电子与信息学院,教授,博士生导师 (Professor)
2021年10月-至今,北京大学现代农业研究院,研究员、课题组长(PI)

 
荣誉和奖励:
2022年  山东省“泰山学者”青年专家

2022年  中国科技期刊卓越行动计划优秀审稿人

2021年  潍坊市“鸢都学者”

2019年  西安交通大学第五届“十大学术新人”
2007年  Penn State University Graham Endowed Fellowship 


主要学术兼职:

Associate Editor for Molecular Plant-Microbe Interactions (Since 2023)

Review Editor for Frontiers in Genetics (Since 2021)

Guest Editor for Plant Physiology and Biochemistry (2022-2023)


研究工作与成果:
     研究方向聚焦在园艺作物与有害生物的功能基因组学和表观转录调控、天然产物的生物合成途径与异源合成、作物病原真菌侵染的化学生物学机制等前沿科学技术问题,以及相关实验计算方法的开发和数据库的搭建,为作物分子育种、食品安全、制药等领域提供理论和技术支撑。研究内容包括三个方面:

1.    作物基因组学与多组学:开展园艺作物的结构、功能和进化基因组学研究,深度挖掘作物多组学数据,鉴定作物优良性状基因,指导分子设计育种;

2.    植物天然产物的生物合成:研究药用植物重要天然活性产物的生物合成途径、调控机制、生物制造;

3.    植物-微生物互作的化学生物学:研究植物病原真菌次生代谢基因簇的功能和调控机制,指导作物真菌病害防治。

研究成果已发表SCI论文36篇,以第一作者或通讯作者身份在Science、PNAS、Nature Communications、New Phytologist、Horticulture Research等多个国际著名期刊上发表SCI论文20篇,参与编写专著3部,申请获批国家发明专利5项;研究成果被Nature, Science, Cell等国际著名期刊引用过百次;主持国家自然科学基金委面上项目、青年项目、国家人社部高层次留学回国人员资助项目,以课题骨干身份参与国家重点研发项目子课题1项;为多个国际权威期刊审稿150余次,被评为2022年度中国科技期刊卓越行动计划优秀审稿人。
     课题组常年招贤纳士,欢迎感兴趣的学生学者和业界人士咨询、加入我们!

 

代表性论文:
 (*: Co-first author; #: Corresponding author)

      1.        Liu H, Wang H, Liao XL, Gao B, Lu X, Sun D, Gong W, Zhong J, Zhu H, Pan X, Guo L#, Deng XW# and Zhou Q#. (2022) Mycoviral gene integration converts a plant pathogenic fungus into a biocontrol agent. Proc Natl Acad Sci USA. 119(50): e2214096119

      2.        Guo L*#, Yao Hui*, Chen W*, Wang X, Ye P, Xu Z, Zhang S,Wu H#. (2022) Natural products of medicinal Plants: biosynthesis and bioengineering in post-genomic era, Horticulture Research. Vol.9: uhac223.

      3.        Wang J*, Li J*#, Li Z, Liu B, Zhang L, Guo D, Huang S, Qian W# , Guo L#. (2022) Genomic insights into longan evolution from a chromosome-level genome assembly and population genomics of longan accessions. Horticulture Research. Vol. 9: uhac021.

      4.        Yang X*, Gao S*, Guo L*, Wang B, Jia Y, Zhou J, Che Y, Jia P, Lin J, Xu T, Sun J, Ye K#. (2021) Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway. Nature Communications. 12:6030.

      5.        Guo L*, Winzer T*, Yang X*, Li Y*, Ning Z*, He Z, Teodor R, Lu Y, Bowser TA, Graham IA#, Ye K#. (2018) The opium poppy genome and morphinan production. Science. 362(6412): p. 343-347.

      6.        Kang Y*, Ji X*, Guo L*, Xia H*, Yang X, Xie Z, Shi X, Wu R, Feng D, Wang C, Chen M, Zhang W, Wei H, Guan Y, Ye K#, Zhao G#. (2021) Cerebrospinal fluid from healthy pregnant women does not harbor a detectable microbial community. Microbiology Spectrum. 9(3): e00769-21.

      7.        Guo L, Ye K#. (2019) Mapping genome variants sheds light on genetic and phenotypic differentiation in Chinese. Genomics, Proteomics & Bioinformatics. 17(3): p226-228

      8.        Guo L, Zhao G, Gao L, Xu JR, Kistler HC, Ma LJ#. (2016) Compartmentalized gene regulatory network of a pathogenic fungus Fusarium graminearum. New Phytologist. 211(2): 527-541.

      9.        Guo L*, Yu H*, Wang B*, Vescio K, Delulio G, Yang H, Berg A, Zhang L, Edel-Hermann V, Steinberg C, Kistler HC, Ma LJ#. (2021) Metatranscriptomic comparison of endophytic and pathogenic Fusarium-Arabidopsis interactions reveals plant transcriptional plasticity. Molecular Plant-Microbe Interactions. 34(9):1071-1083

      10.    Jia Y, Chen S, Chen W, Zhang P, Su Z, Zhang L, Xu M and Guo L#. (2022) A chromosome-level reference genome of Chinese balloon flower (Platycodon grandiflorus). Frontiers in Genetics. 13:869784.

      11.    Wang B, Yu H, Jia Y, Dong Q, Steinberg C, Alabouvette CL, Edel-Hermann V, Kistler HC, Ye K#, Ma LJ#, and Guo L#. (2020) Chromosome-scale genome assembly of strain Fo47, a fungal endophyte and biocontrol agent. Molecular Plant-Microbe Interactions. 33(9):1108-1111

      12.    Wang B*, Guo L*, Ye K#, Wang L#. (2020) Chromosome-scale genome assembly of Talaromyces rugulosus strain W13939, a mycoparasitic fungus and promising biocontrol agent. Molecular Plant-Microbe Interactions. 33(12):1446-1450.

      13.    Shao C*, Xiang D*, Wei H*, Liu S, Yi G, Lyu S#Guo L#, Li C#. (2020) Predicting virulence of Fusarium oxysporum f. sp. cubense based on the production of mycotoxin using a linear regression model. Toxins. 12: 254.

      14.    Xu T, Yang X, Jia Y, Li Z, Tang G, Li X, Wang B, Wang T, Lin J, Guo L, Ye K#. (2022) A global survey of the transcriptome of the opium poppy (Papaver somniferum) based on single-molecule long-read isoform sequencing. The Plant Journal. 110: 607-620.

      15.    Guo L*#, Ji M*, and Ye K#. (2020) Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin production and sexual reproduction in Fusarium graminearumBMC Genomics. 21:179

      16.    Chaisson, M.J.P.*, A.D. Sanders*, X. Zhao*, A. Malhotra, D. Porubsky, T. Rausch, E.J. Gardner, O. Rodriguez, Guo L, R.L. Collins, X. Fan, J. Wen, R.E. Handsaker, S. Fairley, Z.N. Kronenberg, X. Kong, F. Hormozdiari, D. Lee, A.M. Wenger, A. Hastie, D. Antaki, P. Audano, H. Brand, S. Cantsilieris, H. Cao, E. Cerveira, C. Chen, X. Chen, C.-S. Chin, Z. Chong, N.T. Chuang, C.C. Lambert, D.M. Church, L. Clarke, A. Farrell, J. Flores, T. Galeev, D. Gorkin, M. Gujral, V. Guryev, W. Haynes Heaton, J. Korlach, S. Kumar, J.Y. Kwon, J.E. Lee, J. Lee, W.-P. Lee, S.P. Lee, S. Li, P. Marks, K. Viaud-Martinez, S. Meiers, K.M. Munson, F. Navarro, B.J. Nelson, C. Nodzak, A. Noor, S. Kyriazopoulou-Panagiotopoulou, A. Pang, Y. Qiu, G. Rosanio, M. Ryan, A. Stutz, D.C.J. Spierings, A. Ward, A.E. Welch, M. Xiao, W. Xu, C. Zhang, Q. Zhu, X. Zheng-Bradley, E. Lowy, S. Yakneen, S. McCarroll, G. Jun, L. Ding, C.L. Koh, B. Ren, P. Flicek, K. Chen, M.B. Gerstein, P.-Y. Kwok, P.M. Lansdorp, G. Marth, J. Sebat, X. Shi, A. Bashir, K. Ye, S.E. Devine, M. Talkowski, R.E. Mills, T. Marschall, J.O. Korbel#, E.E. Eichler#, and C. Lee#. (2019) Multi-platform discovery of haplotype-resolved structural variation in human genomes. Nature Communications. 10:1784

      17.    Guo L, Breakspear A, Zhao G, Gao L, Kistler HC, Xu JR, Ma LJ#. (2016) Conservation and divergence of the cyclic adenosine monophosphate–protein kinase A (cAMP–PKA) pathway in two plant-pathogenic fungi: Fusarium graminearum and F. verticillioides. Molecular Plant Pathology 17(2): 196-209.

      18.    Guo L, Allen KS, Deiulio GA, Zhang Y, Wick RL, Ma LJ#. (2016) A de-novo-assembly-based pipeline for data mining in plant obligate parasite metatranscriptomic studies. Frontiers in Plant Science. 7: 925