作物开花时间与环境表观遗传学实验室
2025-05-26
实验室、课题组名称：作物开花时间与环境表观遗传学实验室
实验室、课题组负责人：
实验室、课题组介绍：
1、研究方向：植物环境表观遗传学、作物开花时间调控的分子与表观遗传机理
2、主要研究内容：利用分子、生化、遗传及组学等手段，揭示环境信号包括光周期和冬季低温调控植物开花时间（flowering time）的分子与表观遗传机制。种子植物历经营养生长后转换至生殖生长，其转换时机（即成花转变时间或开花时间）受多种内在因子（如年龄、激素等）与外源环境因素（如日照长度变化、温度等）的调控。这些因素通过多种遗传途径如光周期路径、春化路径、年龄路径等，调控开花时间基因的表达，从而诱导植物开花。研究内容：利用模式种子植物以及主粮作物小麦等，聚焦春化路径及光周期路径，揭示季节转换调控越冬植物在春季开花的分子与表观遗传机制；探究冬小麦产量性状形成的分子机制；利用基因编辑等生物技术，遗传改良作物开花时间及产量等农艺性状。
3、主要研究成果：
(1)Niu D, Gao Z, Cui B, Zhang Y, He Y. A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat. Nat Plants. 2024 Jan;10(1):37-52.
(2)Huang F, Luo X, Ou Y, Gao Z, Tang Q, Chu Z, Zhu X, He Y. Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science. 2023 Jul 14;381(6654):eadf8822.
(3)Gao Z, Li Y, Ou Y, Yin M, Chen T, Zeng X, Li R, He Y. A pair of readers of bivalent chromatin mediate formation of Polycomb-based "memory of cold" in plants. Mol Cell. 2023 Apr 6;83(7):1109-1124.e4.
(4)Zhang Z, Luo X, Yang Y, He Y. Cold induction of nuclear FRIGIDA condensation in Arabidopsis. Nature. 2023 Jul;619(7969):E27-E32.
(5) Xu G, Tao Z, He Y. Embryonic reactivation of FLOWERING LOCUS C by ABSCISICACID-INSENSITIVE 3 establishes the vernalization requirement in each Arabidopsisgeneration. (2022) Plant Cell. May 24;34(6):2205-2221.
(6)Li Z., Luo X., Ou Y., Jiao H., Peng L., Fu X., Macho A.P., Liu R., and He Y. JASMONATE-ZIM DOMAINproteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis. (2021) Mol. Plant. 14,732–747.
(7)Luo X, Ou Y, Li R, and He Y. (2020) Maternal transmission of the epigenetic 'memory of winter cold' in Arabidopsis. Nature Plants, 6: 1211-1218.
(8)Tao Z, Hu H, Luo X, Jia B, Du J*, He Y.* (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants, 5: 424-435.
(9) Luo, X., Chen, T., Zeng, X.L., He, D.W., and He Y. (2019) Feedback regulation of FLC by FLOWERING LOCUS T (FT) and FD through a 5' FLC promoter region in Arabidopsis. Molecular Plant, 12: 285-288.
(10) Li Z, Fu X, Wang Y, Liu R and He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics, 50: 1254-1261.
(11) Li Z, Jiang D and He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 4: 836-846.
(12) Z. Li, Y. Ou, J. Li and He Y. (2018) Brassinosteroid signaling recruits Histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Molecular Plant, 11: 1135-1146.
(13) Y. He & Li Z. (2018) Epigenetic environmental memories in plants: establishment, maintenance, and reprogramming. Trends in Genetics, 34: 856-866.
(14) Z. Tao, L. Shen, X. Gu, Y. Wang, H. Yu & He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature, 551: 124-128.
(15) Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J & He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics, 48: 1527-1534.
(16) Li Z, Jiang D, Fu X, Luo X, Liu R & He Y. (2016) Integration of histone methylations with RNA processing by the nuclear mRNA Cap Binding Complex. Nature Plants, 2: 16015.
团队成员：
团队介绍：团队共18人，副研究员2人，助理研究员5人，科研助理6人，行政助理1人，联培学生2人，在读博士1人。
主要成员介绍：
姓名：牛德
职务：副研究员
教育背景与工作经历：
2003.09-2007.06 南阳师范学院 生物工程 本科
2007.09-2010.06 东北农业大学 植物学 硕士
2011.09-2017. 06 中国科学院 植物研究所 发育生物学 博士
2017.07-2018.12 中国科学院 植物研究所 博士后
2019.01-2020.11 中国科学院 分子植物科学卓越创新中心 博士后
2020.12-至今 北京大学现代农业研究院 副研究员
研究方向：小麦开花时间的分子与表观遗传调控机制
文章：
[1] Jing H, Liu W, Qu GP, Niu D, Jin JB. SUMOylation of AL6 regulates seed dormancy and thermoinhibition in Arabidopsis. New Phytol. 2025 Feb;245(3):1040-1055
[2] Pan W*, Gao C*, Niu D*, Cheng J, Zhang J, Yan X, Long Q, Zhu Y, Sun W, Xie Q, He Y, Deng XW, Zhang H, Li J. Efficient gene disruption in polyploid genome by Cas9-Trex2 fusion protein. J Integr Plant Biol. 2025 Jan;67(1):7-10
[3] Niu D, Gao Z, Cui B, Zhang Y, He Y. A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat. Nat Plants. 2024 Jan;10(1):37-52
[4] Niu D, He Y. LEAFY COTYLEDONs: old genes with new roles beyond seed development. F1000Res. 2019 Dec 27;8:F1000 Faculty Rev-2144
[5] Niu D, Lin XL, Kong X, Qu GP, Cai B, Lee J, Jin JB. SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis. Mol Plant. 2019 Feb 4;12(2):215-228.
[6] Liu P, Zhang S, Zhou B, Luo X, Zhou XF, Cai B, Jin YH, Niu D, Lin J, Cao X, Jin JB. The Histone H3K4 Demethylase JMJ16 Represses Leaf Senescence in Arabidopsis. Plant Cell. 2019 Feb;31(2):430-443.
[7] Lin XL, Niu D, Hu ZL, Kim DH, Jin YH, Cai B, Liu P, Miura K, Yun DJ, Kim WY, Lin R, Jin JB. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity. PLoS Genet. 2016 Apr 29;12(4):e1006016.
[8] Wang W, Tang W, Ma T, Niu D, Jin JB, Wang H, Lin R. A pair of light signaling factors FHY3 and FAR1 regulates plant immunity by modulating chlorophyll biosynthesis. J Integr Plant Biol. 2016 Jan;58(1):91-103.
姓名：沈超
职务：副研究员
教育背景与工作经历
2010–2014 本科，园艺，浙江农林大学
2014–2017 硕士，林木遗传育种，浙江农林大学
2017–2021 博士，植物学，北京林业大学
2021–2022 博士后，西湖大学
2022–至今 副研究员，北京大学现代农业研究院
研究方向：
利用分子、生化、遗传及结构生物学等手段，揭示冬小麦春化作用及产量性状形成的分子与表观遗传机制。
文章
[1] Shen Chao, Li Qing, An Yi, Zhou Yang-yan, Zhang Yue, He Fang, Chen Lin-yun, Mao Wei,Wang Xiao-fei, Liang Hai-ying, Yin Wei-lun, Xia Xin-li. 2022. The transcription factor GNCoptimizes nitrogen use efficiency and growth by driving the expression of nitrate uptake andassimilation genes in poplar. Journal of Experimental Botany.
[2] Shen Chao, Zhang Yue, Li Qing, Liu Shu-jing, He Fang, An Yi, Zhou Yang-yan, Liu Chao, YinWei-lun, Xia Xin-li*. (2021). PdGNC confers drought tolerance by mediating stomatal closureresulted from NO and H O production via the direct regulation of PdHXK1 expression in Populus.New Phytol. 2021 Jun; 230(5): 1868-1882.
[3] Qing Li , Chao Shen (共同一作), Yue Zhang, Yangyan Zhou, Mengxue Niu, Hou-Ling Wang,Conglong Lian, Qianqian Tian, Wei Mao, Xiaofei Wang, Chao Liu, Weilun Yin, Xinli Xia. 2022.PePYL4 enhances drought tolerance by modulating water-use efficiency and ROS scavenging inPopulus. Tree Physiol. doi: 10.1093/treephys/tpac106.
[4] Zhang Yue#, Shen Chao# (共同一作), Zhou Yang-yan, Liu Chao, Yin Weilun, Xia Xinli*. (2021).Tuning drought resistance by using a root-specific expression transcription factor PdNF-YB21 inArabidopsis thaliana. Plant Cell Tiss Organ Cult。145:379–391。