迟程 蛋白质结构与功能研究组课题组长
邮箱：cheng.chi@pku-iaas.edu.cn
研究方向：植物蛋白质结构与功能研究
个人简介：
2012.09 - 2016.06，南京农业大学园艺学院，学士学位
2016.09 - 2021.06，浙江大学农业与生物技术学院，博士学位
2021.09 - 2023.08，北京大学现代农学院，博士后
2023.09 - 2025.09，北京大学现代农业研究院，副研究员
2025.10 - 至今，北京大学现代农业研究院，课题组长
主要荣誉：
2023年泰山学者青年专家
北大-清华生命科学联合中心杰出博士后
社会兼职：
2026.05-至今，青年编委，Horticulture Research期刊
研究领域及成果：
本人主要从事植物蛋白质结构与功能研究，结合结构生物学、遗传学、电生理等技术，重点解析植物受体激酶、光敏色素蛋白及膜蛋白的结构基础与作用机制，关注植物信号感知、生长发育调控和逆境响应，为植物学基础研究与作物改良提供理论支撑。
以第一或通讯作者（含共同）在Nature，Nature Plants，Nature Communications，Molecular Plant等期刊进行论文发表，获得山东省泰山学者青年专家荣誉，主持国家自然科学基金1项，山东省自然科学基金2项，以及中国博士后面上项目和北大-清华生命科学联合中心博士后基金。
代表性论文：
(#: first author; *: corresponding author)
1. Lijun Wang#, Jun Zhao#, Chuanchun Yin#, Hongxu Li, Yanan Xiao, Cuicui Du, Zhaoxi Lu, Yongjian Zhang, Fangshuai Jia, Jiaxin Hao, Jinghui Yan, Yi Zhang, Jian Li, Xinhua Ding, Zhifu Han, Haitao Cui, Jijie Chai, Xingwang Deng, Cheng Chi*, Shuguo Hou*. 2025. Recognition of a phytocytokine by the DEPR1-SERK2 receptor complex confers multi-pathogen resistance in wheat. Molecular Plant 18:1999-2017.
2. Zhengdong Wang#, Wenfeng Wang#, Didi Zhao#, Yanping Song#, Xiaoli Lin#, Meng Shen, Cheng Chi, Bin Xu, Jun Zhao, Xing Wang Deng*, Jizong Wang*. 2024. Light-induced remodeling of phytochrome B enables signal transduction by phytochrome- interacting factor. Cell 187:6235-6250.
3. Cheng Chi#, Zhengdong Wang#, Ruihan Wang, Jizong Wang*. 2025. Production of plant phytochromes by combining insect cells and bacterial expression systems. Methods in Molecular Biology 2970:69-80.
4. Huiwen Chen#, Junping Fan#, Cheng Chi#, Jun Zhao#, Di Wu, Xiaoguang Lei*, Xing Wang Deng*, Daohua Jiang*. 2025. Structural basis of auxin recognition and transport by the plant influx carrier AUX1. Molecular Plant 18:1284-1293.
5. Ke Wang#, Junping Fan#*, Huiwen Chen#, Bo Huang#, Cheng Chi#, Rui Yan, Di Wu, Feng Zhou, Wenhua Zhang, Juquan Jiang*, Xiaoguang Lei*, Daohua Jiang*. 2026. Structure and mechanism of the human bile acid transporter OSTα/OSTβ. Nature 651:251-259.
6. Changshi Wang#, Cheng Chi#, Yuelin Liu, Jun Zhao, Qian Wang, Nana Wang, Zhihui Zhang, Kai Jiang, Yan Xue, Yong Li, Peiyi Wang, Jixian Zhai, Hongwei Guo, Jiamu Du*. 2026. Molecular basis of DRB4-assisted long RNA processing and 21-nt siRNA biogenesis by DCL4 in plants. Nature Plants 12:512-519.
7. Rui Yan#, Junping Fan#, Cheng Chi#, Di Wu, Huiwen Chen, Jianke Gong, Xiaoguang Lei, Daohua Jiang. 2026. Structural basis of glucosinolate recognition and transport by plant GTR1. Cell Discovery 12:26.
8. Zhihui Zhang#, Wentao Li#, Yue Liu#, Cheng Chi#, Jing Nan, Changshi Wang, Yongkun Zhu, Jun Zhao, Yan Xue, Yong Li, Peiyi Wang, Jixian Zhai, Jiamu Du*. 2025. Structural insights into plant DNA CG methylation maintenance by MET1. The Plant Cell 37:koaf244.
9. Guohui Xie#, Xuan Du#, Yifang Tan#, Yuxing Zhou#, Cheng Chi#, Sixian Zhou, Colette Picard, Lei Wu, Danling Zhu, Jun Zhao, Yan Xue, Sisi Li, Steven Jacobsen, Zhe Wu, Jiamu Du*. 2026. A spontaneous termination mechanism of RNA polymerase V shapes the DNA methylation landscape in plants. The EMBO Journal 45:3192-3205.
10. Jinwei Yang#, Hongna Li#, Mengyu Li#, Rui Song#, Tao Shen, Guiping Wang, Dong Xu, Ming Hao, Aolin Jia, Shams ur Rehman, Lei Hua, Yanyan Liang, Cheng Chi, Caixia Lan, Xing Wang Deng, Jorge Dubcovsky, Baoxing Song*, Xiaodong Wang*, Shisheng Chen*. 2025. Genome-assisted identification of wheat leaf rust resistance gene Lr.ace-4A/Lr30. Nature Communications 16:9339.
11. Cheng Chi#, Xinlin Chen#, Changan Zhu, Jiajian Cao, Hui Li, Ying Fu, Guochen Qin, Jun Zhao*, Jingquan Yu, Jie Zhou*. 2025. Strigolactones positively regulate HY5-dependent autophagy and the degradation of ubiquitinated proteins in response to cold stress in tomato. New Phytologist 245:1106-1123.
12. Cheng Chi, Xuechen Xu, Mengqi Wang, Hui Zhang, Pingping Fang, Jie Zhou, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jingquan Yu*. 2021. Strigolactones positively regulate abscisic acid-dependent heat and cold tolerance in tomato. Horticulture Research 8:237.
13. Cheng Chi, Xiaomeng Li, Pingping Fang, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jie Zhou*, Jingquan Yu. 2020. Brassinosteroids act as a positive regulator of NBR1-dependent selective autophagy in response to chilling stress in tomato. Journal of Experimental Botany 71:1092-1106.
14. Chao-Chao Liu, Cheng Chi, Li-Juan Jin, Jianhua Zhu, Jing-Quan Yu, Yan-Hong Zhou. 2018. The bZip transscription factor HY5 mediates CRY1a-induced anthocyanin biosynthesis in tomato. Plant, Cell & Environment 41:1762-1775.
15. Pingping Fang, Mengyu Yan, Cheng Chi, Mengqi Wang, Yanhong Zhou, Jie Zhou, Kai Shi, Xiaojian Xia, Christine H. Foyer, Jingquan Yu. 2019. Brassinosteroids act as a positive regulator of photoprotection in response to chilling stress. Plant Physiology 180:2061-2076.
16. Xuechen Xu, Pingping Fang, Hui Zhang, Cheng Chi, Liuxia Song, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jie Zhou, Jingquan Yu. 2019. Strigolactones positively regulate defense against root-knot nematodes in tomato. Journal of Experimental Botany 70:1325-1337.
17. Pingping Fang, Yu Wang, Mengqi Wang, Feng Wang, Cheng Chi, Yanhong Zhou, Jie Zhou, Kai Shi, Xiaojian Xia, Christine H. Foyer, Jingquan Yu. 2021. Crosstalk between Brassinosteroid and redox signaling contributes to the activation of CBF expression during cold responses in tomato. Antioxidants 10:509.
18. Mingming He#, Jiating Wu#, Yan Yang#, Qingshen Cui, Nuo Fan, Cheng Chi, Huan Yan, Yihao Liu, Zonghua Pan, Ke Zhang, Jian Wang, Xiaoying Liu, Jin Sun, Shirong Guo, Yu Wang*. 2025. The HsfA1a-BAG5b module mediates thermotolerance through activating autophagy in tomato. Plant Physiology 199:kiaf526.