薛彦 作物抗逆实验室主任
邮箱：yan.xue@pku-iaas.edu.cn
研究方向：辣椒抗逆机制研究及作物改良
个人简介:
2007年5月 香港中文大学 学士
2009年5月 香港中文大学 硕士
2017年5月 杜克大学 博士
2017年11月-2022年4月 加州大学洛杉矶分校 博士后
2022年7月至今 北京大学现代农业研究院
研究领域：
全球气候变化以及大规模的单一种植，使得作物更频繁的受到温度和疾病的胁迫。温度胁迫影响植物生长发育的每个阶段，造成严重减产；且高温高湿环境更容易导致病毒病的大规模爆发。目前对于病毒病的爆发，我们尚无有效的治理措施。辣椒是我国经济价值最高的作物，其对于温度和病毒极为敏感。本课题组针对辣椒应对高低温胁迫以及病毒病的抗性进行研究。具体研究方向包括：
1. 品种资源收集和筛选对于高低温和病毒病具有抗性的辣椒品种，并在此基础上通过育种，对辣椒进行品种改良。
2. 对具有抗性的辣椒品种进行深入的分子机制研究。
发表论文：
1. Ye Liu*, Yingjie Mi*, Manru Song*, Hongji Yang*, Lulu Liu, Qian Yin, Xueyan Yao, Guorong Yu, Ying Fu, Guochen Qin, Feng Liu#, Xuan Huang#, Yan Xue#. Features of DNA methylome in Capsicum spp. (2025) Chromatin and Epigenetics.
2. Zhongshou Wu, Yan Xue, Shuya Wang, Yuan-Hsin Shih, Zhenhui Zhong, Suhua Feng, Jonathan Draper, Allen Lu, Carsten A. Hoeke, Jihui Sha, James Wohlschlegel, Keqiang Wu, Steven E. Jacobsen. REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes. (2025) Nature Cell Biology, 27: 1136-1147.
3. Zhihui Zhang, Wentao Li, Yue Liu, Cheng Chi, Jing Nan, Changshi Wang, Yongkun Zhu, Jun Zhao, Yan Xue, Yong Li, Peiyi Wang, Jixian Zhai, Jiamu Du. Structural insights into plant DNA CG methylation maintenance by MET1. (2025) Plant Cell. doi: 10.1093/plcell/koaf244.
4. Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu*, Zhenhui Zhong*, Yan Xue*. Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper. (2025) Genome Biology, 26:121.
5. Yan Xue*, Xiaofeng Cao*, Xiangsong Chen*, Xian Deng*, Xing Wang Deng*, Yong Ding*, Aiwu Dong*, Cheng-Guo Duan*, Xiaofeng Fang*, Lei Gong*, Zhizhong Gong*, Xiaofeng Gu*, Chongsheng He*, Hang He*, Shengbo He*, Xin-Jian He*, Yan He*, Yuehui He*, Guifang Jia*, Danhua Jiang*, Jianjun Jiang*, Jinsheng Lai*, Zhaobo Lang*, Chenlong Li*, Qing Li*, Xingwang Li*, Bao Liu*, Bing Liu*, Xiao Luo*, Yijun Qi*, Weiqiang Qian*, Guodong Ren*, Qingxin Song*, Xianwei Song*, Zhixi Tian*, Jia-Wei Wang*, Yuan Wang*, Liang Wu*, Zhe Wu*, Rui Xia*, Jun Xiao*, Lin Xu*, Zheng-Yi Xu*, Wenhao Yan*, Hongchun Yang*, Jixian Zhai*, Yijing Zhang*, Yusheng Zhao*, Xuehua Zhong*, Dao-Xiu Zhou*, Ming Zhou*, Yue Zhou*, Bo Zhu*, Jian-Kang Zhu* & Qikun Liu*. Epigenetics in the modern era of crop improvements. (2025) Science China Life Sciences, https://doi.org/10.1007/s11427-024-2784-3
6. Zhong, Z.*, Xue, Y.*, Harris CJ.*; Wang, M., Li, Z., Ke, Y., Jami-Alahmadi, Y., Feng, S., Wohlschlegel, J. and Jacobsen, SE. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. (2023) Genome Biology, 24:96.
7. Wang, Q.,* Xue, Y.,* Zhang, L.,* Zhong, Z., Feng, S., Wang, C., Xiao, L., Yang, Z., Harris, CJ., Wu, Z., Zhai, J.,Yang, M., Li, S., Jacobsen, SE. and Du, J. (2021) Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374:1152-1157.
*Equal contribution
8. Xue, Y.*, Zhong Z.*, Harris CJ.*, Gallego-Bartolomé, J., Wang, M., Picard, C., Cao, X., Hua, S., Kwok, I., Feng, S., Jami-Alahmadi, Y., Sha, J., Gardiner, J., Wohlschlegel, J. and Jacobsen, SE. (2021) Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature Communications, 12:4292.
9. Jiang, Z., Zhou, X., Tao, M., Yuan, Y., Liu, L., Wu, F., Wu, X., Xiang, Y., Niu, Y., Liu, F., Li, C., Ye, R., Byeon, B., Xue, Y., Zhao, H., Wang, S., Crawford, B., Johnson, M., Hu, C., Pei, C., Zhou, W., Swift, G., Zhang, H., Vo-Dinh, T., Hu, Z., Siedow, J. and Pei, Z. (2019) Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx. Nature, 572: 341-346.
10. Kim, HJ., Yen, L, Wongpalee, SP., Kirshner, JA., Mehta, N., Xue, Y., Johnston, JB., Burlingame, AL., Kim, JK., Loparo JJ., and Jacobsen, SE. (2019). The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction. Molecular Cell, 75: 700-71
11. Harris, CJ., Scheibe, M., Wongpalee, SP., Liu, W., Cornett, EM., Vaughan, RM., Li, X., Chen, W., Xue, Y., Zhong, Z., Yen, L., Barshop, WD., Rayatpisheh, S., Gallego-Bartolome, J., Groth, M., Wang, Z., Wohlschlegel, JA., Du, J., Rothbart, SB., Butter, F., and Jacobsen, SE. (2018). A DNA methylation reader complex that enhances gene transcription. Science, 6419: 1182-1186.
12. Yuan, F., Yang, H.*; Xue, Y.*; Kong, D., Ye, R., Li, C., Zhang, J., Theprungsirikul, L.,Shrift, T., Krichilsky, B., Johnson, DM., Swift, GB., He, Y., Siedow, JN. and Pei, ZM.(2014). OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing inArabidopsis. Nature. 514: 367-371*equal contribution
13. Jiang, Z., Zhu, S., Ye, R., Xue, Y., Chen, A., An, L. and Pei, ZM. (2013). Relationship between NaCl- and H2O2-Induced cytosolic Ca2+ Increases in response to stress in Arabidopsis. PloS one. 8: 10
14. Cheung, MY., Xue, Y., Zhou, L., Li, MW., Sun, SSM. and Lam, HM. (2010) An ancient Ploop GTPase in rice is regulated by a higher plant-specific regulatory protein. Journal of Biololgical Chemistry. 285:37359–37369.
15. Cheung, MY., Zeng, NY., Tong, SW., Li, FWY., Xue, Y., Zhao, KJ., Wang, C., Zhang, Q., Fu, Y., Sun, Z., Sun, SSM. and Lam, HM. (2008) Constitutive expression of a rice GTPase activating protein induces defense responses. New Phytologist. 179:530-545