小麦雄蕊发育机制研究与应用实验室
2025-01-21
实验室名称：小麦雄蕊发育机制研究与应用实验室
实验室负责人：李磊
邮箱：lei.li@pku-iaas.edu.cn
教育经历
1992 － 1997，理学学士，北京大学生命科学学院
1997 － 2003，博士，美国密歇根州立大学MSU-DOE植物研究实验室
2003 － 2007，博士后，美国耶鲁大学分子细胞发育生物学系
工作经历
2007年 - 2014年，美国弗吉尼亚大学生物系，助理教授，博士生导师
2014年 - 2024年，研究员，北京大学生命科学学院、北京大学现代农学院、北大-清华联合生命中心，博士生导师
2024年-至今 ，资深研究员，北京大学现代农业研究院
研究方向：
一、小麦雄蕊发育的调控机制；
二、铜信号在植物发育与环境适应中的转导机制与功能。
这些研究旨在加深和拓展对植物特有生命现象的认识，为农业生物技术提供新的理论基础与操作思路。
近五年代表性论文：
1.Yang Y, Xu L, Hao C, Wan M, Tao Y, Zhuang Y, Su Y, Li L* (2024) The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells. The Plant Cell, 36(10):4338-4355.
2.Hao Y, Yang Y, Tu H, Guo Z, Chen P, Chao X, Yuan Y, Wang Z, Miao X, Zou S, Li D, Yang Y, Wu C, Li B, Li L*, Cai H* (2024) A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition. Developmental Cell, 59(5):645-660.
3.Shen F, Qin Y, Wang R, Huang X, Wang Y, Gao T, He J, Zhou Y, Jiao Y, Wei J*, Li L*, Yang X* (2023) Comparative genomics reveals a unique nitrogen-carbon balance system in Asteraceae. Nature Communications, 14(1):4334.
4.Xu L, Tang Y, Yang Y, Wang D, Wang H, Du J, Bai Y, Su S, Zhao C*, Li L* (2023) Microspore expressed SCULP1 is required for p-coumaroylation of sporopollenin, exine integrity, and pollen development in wheat. New Phytologist, 239(1):102-115.
5.Gao Z, Li J, Li L, Yang Y, Li J, Fu C, Zhu D, He H, Cai H, Li L* (2022) Structural and functional analyses of hub microRNAs in an integrated gene regulatory network of Arabidopsis. Genomics Proteomics Bioinformatics, 20(4):747-764.
6.Guo Z, Kuang Z, Tao Y, Wang H, Wan M, Hao C, Shen F, Yang, X*, Li L* (2022) Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms. Molecular Biology and Evolution, 39(11):msac224.
7.Yang Y, Hao C, Du J, Xu L, Guo Z, Li D, Cai H, Guo H, Li L* (2022) The carboxy terminal transmembrane domain of SPL7 mediates interaction with RAN1 at the endoplasmic reticulum to regulate ethylene signaling in Arabidopsis. New Phytologist, 236(3):878-892.
8.Hao C, Yang Y, Du J, Deng XW*, Li L* (2022) The PCY-SAG14 phytocyanin module regulated by PIFs and miR408 promotes dark-induced leaf senescence in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 119(3):e2116623119.
9.Guo Z, Kuang Z, Zhao Y, Deng Y, He H, Wan M, Tao Y, Wang D, Wei J, Li L*, Yang X* (2022) PmiREN2.0: from data annotation to functional exploration of plant microRNAs. Nucleic Acids Research, 50(D1):D1475-D1482.
10.Jiang A, Guo Z, Pan J, Zhuang Y, Zuo D, Hao C, Gao Z, Xin P, Chu J, Zhong S, Li L* (2021) The PIF1-MIR408-Plantacyanin repression cascade regulates light dependent seed germination. The Plant Cell, 33(5):1506-1529.
11.Zhang H, Guo Z, Zhuang Y, Suo Y, Du J, Gao Z, Pan J, Li L, Wang T, Xiao L, Qin G, Jiao Y, Cai H, Li L* (2021) MicroRNA775 promotes intrinsic leaf size and reduces cell wall pectin level via a target galactosyltransferase in Arabidopsis. The Plant Cell, 33(3):581-602.
12.Zhuang Y, Zuo D, Tao Y, Cai H*, Li L*. (2020) Laccase3-based extracellular domain provides possible positional information for directing Casparian strip formation in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 117:15400-15402.
13.Guo Z, Kuang Z, Wang Y, Zhao Y, Tao Y, Cheng C, Yang J, Lu X, Hao C, Wang T, Cao X, Wei J, Li L*, Yang X*. (2020) PmiREN: a comprehensive encyclopedia of plant miRNAs. Nucleic Acids Research, 48:D1114-D1121.
姓名：杨彦芝
职务：副研究员
邮箱：yanzhi.yang@pku-iaas.edu.cn
教育背景：2010/09—2014/06北京林业大学生物科学与技术学院 国家生物学理科基地班 理学学士
2014/09—2020/06北京大学生命科学学院 生物化学与分子生物学 理学博士
工作经历：2020/07—2024/08 北京大学现代农学院 博士后
2024/09—至今 北京大学现代农业研究院 副研究员
研究方向：植物逆境胁迫响应的分子机制研究
文章：1.Yang, Y., Xu, L., Hao, C., Wan, M., Tao, Y., Zhuang, Y., Su, Y., Li, L*. (2024) The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells. The Plant Cell 36(10):4338-4355. （该论文被Trends in Plant Science亮点推荐）
2.Yang, Y., Hao, C., Du, J., Xu, L., Guo, Z., Li, D., Cai, H., Guo, H., Li, L*. (2022) The Carboxy Terminal Transmembrane Domain of SPL7 Mediates Interaction with RAN1 at the Endoplasmic Reticulum to Regulate Ethylene Signaling in Arabidopsis. New Phytologist 236(3):878-892.
3.Hao, C., Yang, Y., Du, J., Deng, X.W.*, Li, L*. (2022) The PCY-SAG14 phytocyanin module regulated by PIFs and miR408 promotes dark-induced leaf senescence in Arabidopsis. PNAS 119(3): e2116623119.
4.Xu, L.#, Tang, Y.#, Yang, Y., Wang, D., Wang, H., Du, J., Bai, Y., Su, S., Zhao, C., Li, L*. (2023) Microspore-expressed SCULP1 is required for p-coumaroylation of sporopollenin, exine integrity, and pollen development in wheat. New Phytologist 239(1):102-115.
5.Jiang, A., Guo, Z., Pan, J., Yang, Y., Zhuang, Y., Zuo, D., Hao, C., Gao, Z., Xin, P., Chu, J., Zhong, S., and Li, L*. (2021) The PIF1-miR408-PLANTACYANIN repression cascade regulates light-dependent seed germination. The Plant Cell 33(5): 1506–1529.
6.Gao, Z.#, Li, J.#, Li, L., Yang, Y., Li, J., Fu, C., Zhu, D., He, H., Cai, H., Li, L*. (2022) Structural and Functional Analyses of Hub MicroRNAs in an Integrated Gene Regulatory Network of Arabidopsis. Genomics, Proteomics & Bioinformatics 20(4):747-764.
7.Hao, Y., Yang, Y., Tu, H., Guo, Z., Chen, P., Chao, X., Yuan, Y., Wang, Z., Miao, X., Zou, S., Li, D., Yang, Y., Wu, C., Li, B., Li, L.*, Cai, H*. (2024) A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition. Developmental Cell 59(5):645-660.e8.
8.Xu, D., Tang, W., Ma, Y., Wang, X., Yang, Y., Wang, X., Xie, L., Huang, S., Qin, T., Tang, W., Xu, Z., Li, L.*, Tang, Y.*, Chen, M.*, Ma, Y.* (2024) Arabidopsis G-protein β subunit AGB1 represses abscisic acid signaling via attenuation of the MPK3-VIP1 phosphorylation cascade. Journal of Experimental Botany 75(5):1615-1632.
姓名：次东
职务：副研究员
邮箱：dong.ci@pku-iaas.edu.cn
教育背景：
2018.9-2019.6 北京林业大学林木遗传育种专业获得博士学位
2017.9-2018.9 联合培养博士in Warnell School of Forestry and Natural Resources, Dept. Genetics, University of Georgia
2012.9-2017.9 北京林业大学林木遗传育种专业攻读博士学位
2008.9-2012.6 北京林业大学生物技术专业获得理学学士学位
工作经历：
2021.11-至今 北京大学现代农业研究院/潍坊现代农业山东省实验室 副研究员
2019.9-2021.11 北京大学生命科学学院 博士后
研究方向：
植物抗逆及生殖发育，以及铜离子在植物抗逆中的分子机制
文章：
1.Dong Ci #, Min Tian #, Yuepeng Song, Qingzhang Du, Mingyang Quan, Anran Xuan, Jianyuan Yu, Zixuan Yuan, Deqiang Zhang. "Indole-3-acetic acid has long-term effects on long non-coding RNA gene methylation and growth in Populus tomentosa." Molecular Genetics and Genomics (2019): 1-15.
2.Min Tian #, Dong Ci #, Yuepeng Song and Deqiang Zhang. "Transcriptional regulation of chilling stress responsive long noncoding RNAs in Populus simonii." Trees (2018) (Received at 2018.8).
3.Dong Ci, Yuepeng Song, Qingzhang Du, Min Tian, Shuo Han, and Deqiang Zhang. "Variation in genomic methylation in natural populations of Populus simonii is associated with leaf shape and photosynthetic traits." Journal of experimental botany 67, no. 3 (2016): 723-737.
4.Dong Ci, Yuepeng Song, Min Tian, and Deqiang Zhang. "Methylation of miRNA genes in the response to temperature stress in Populus simonii."Frontiers in plant science 6 (2015).
5.Yuepeng Song, #, Dong Ci #, Min Tian, and Deqiang Zhang. "Stable methylation of a non-coding RNA gene regulates gene expression in response to abiotic stress in Populus simonii." Journal of experimental botany (2015): erv543.
6.Qingshi Wang, #, Dong Ci #, Tong Li, Peiwen Li, YuePeng Song, Jinhui Chen, Mingyang Quan, Daling Zhou, and Deqiang Zhang. "The Role of DNA Methylation in Xylogenesis in Different Tissues of Poplar." Frontiers in Plant Science 7 (2016).
7.Bewg, William Patrick, Dong Ci, and Chung-Jui Tsai. "Genome Editing in Trees: from multiple repair pathways to long-term stability." Frontiers in plant science 9 (2018).
8.Jianbo Xie, Kecheng Qian, Jingna Si, Liang Xiao, Dong Ci, and Deqiang Zhang. Conserved noncoding sequences conserve biological networks and influence genome evolution. Heredity (2018) doi: 10.1038/s41437-018-0055-4
9.Yuepeng Song, Anran Xuan, Chenhao Bu, Dong Ci, Min Tian, Deqiang Zhang. "Osmotic stress‐responsive promoter upstream transcripts (PROMPT s) act as carriers of MYB transcription factors to induce the expression of target genes in Populus simonii." (2018) Plant Biotechnology Journal.
10.Yuepeng Song, Min Tian, Dong Ci, and Deqiang Zhang. "Methylation of microRNA genes regulates gene expression in bisexual flower development in andromonoecious poplar." Journal of experimental botany (2015): eru531.
11.Yuepeng Song, Dong Ci, Min Tian, and Deqiang Zhang. "Comparison of the physiological effects and transcriptome responses of Populus simonii under different abiotic stresses." Plant molecular biology 86, no. 1-2 (2014): 139-156.
12.Yuepeng Song, Kaifeng Ma, Dong Ci, Qingqing Chen, Jiaxing Tian, and Deqiang Zhang. "Sexual dimorphic floral development in dioecious plants revealed by transcriptome, phytohormone, and DNA methylation analysis in Populus tomentosa." Plant molecular biology 83, no. 6 (2013): 559-576.
13.Yuepeng Song, Kaifeng Ma, Dong Ci, Zhiyi Zhang, and Deqiang Zhang. "Biochemical, physiological and gene expression analysis reveals sex‐specific differences in Populus tomentosa floral development." Physiologia plantarum 150, no. 1 (2014): 18-31.
14.Yuepeng Song, Kaifeng Ma, Dong Ci, Zhiyi Zhang, and Deqiang Zhang. "Sexual dimorphism floral microRNA profiling and target gene expression in andromonoecious poplar (Populus tomentosa)." PloS one 8, no. 5 (2013): e62681.
15.Yuepeng Song, Qingqing Chen, Dong Ci, and Deqiang Zhang. "Transcriptome profiling reveals differential transcript abundance in response to chilling stress in Populus simonii." Plant cell reports 32, no. 9 (2013): 1407-1425.
16.Yuepeng Song, Kaifeng Ma, Dong Ci, Xueyuan Tian, Zhiyi Zhang, and Deqiang Zhang. "The SUPERMAN gene family in Populus: nucleotide diversity and gene expression in a dioecious plant." Plant cell reports 32, no. 8 (2013): 1277-1288.
17. Yuepeng Song, Qingqing Chen, Dong Ci, Xinning Shao, and Deqiang Zhang. "Effects of high temperature on photosynthesis and related gene expression in poplar." BMC plant biology 14, no. 1 (2014): 1.
18.Jiaxing Tian, Yuepeng Song, Qingzhang Du, Xiaohui Yang, Dong Ci, Jinhui Chen, Jianbo Xie, Bailian Li, and Deqiang Zhang*. Population genomic analysis of gibberellin-responsive long noncoding RNAs in Populus. Journal of Experimental Botany, 2016, 67(8): 2467-2482.
专利：
张德强，次东。“抗逆杨树的分子标记、筛选方法、试剂盒及应用”，专利号：ZL
201310298867.5。
张德强，次东，宋跃鹏。“一种基因组胞嘧啶位点表观基因型分型方法”，专利号：ZL 201710064216.8。
张德强，宋跃朋，次东。“一种响应逆境胁迫的lncRNAs二级结构功能注释方法”，专利号：ZL 201710120768.6。
张德强，次东，宋跃鹏。“确定预定物种的基因表达和甲基化修饰调控的关系的方法”，
专利号：ZL 201710145929.7
张德强，宋跃朋，次东。“一种高分辨率核酸结合熔解荧光的检测方法”，专利
号：ZL 201710118877.4。
张德强，宋跃朋，次东。“一种植物响应逆境胁迫的lncRNAs序列模块功能注释方法”，
专利号：ZL 201710120750.6。
姓名：刘青青
职务：助理研究员
邮箱：799719775@qq.com
教育背景： 南京农业大学
农业昆虫与害虫防治 2016.09-2024.06 （硕博连读）
河南农业大学 植物保护 2012.9-2016.7 本科
研究方向：植物气孔开合调控的信号转导和分子机制
文章： Shi Yu#, Liu Qingqing#, Lu Wenjie, Yuan Jing, Yang Yihua, Oakeshott John, Wu Yidong.Divergent amplifications of CYP9A cytochrome P450 genes provide two noctuid pests with differential protection against xenobiotics[J]. Proceedings of the National Academy of Sciences of the United State
姓名：张振京
职务：科研助理
邮箱： surprisingzhang@163.com
教育背景：华东师范大学 硕士
工作经历：上海药明康德新药开发有限公司 副高级研究员
研究方向：蛋白质功能与结构
荣誉 ：上海市优秀毕业生
文章 ：“The fluorination effect of fluoroamphiphiles in cytosolic protein delivery ” Nat. Commun. 2018，9，1377
专利 ：一种用于蛋白质胞内递送的含氟化合物
姓名：朱姣姣
职务：行政助理
邮箱：zhuli18158951214@163.com
教育背景：安徽万博科技职业学院
姓名：刘亚男
职务：科研助理
邮箱：18763826178@163.com
教育背景：2016.09- 2018.06
中国农业大学 种子科学与技术专业 农学硕士
工作经历：
2019.08- 2023.01
北京爱学习博乐教育科技有限公司 PMO/项目经理
荣誉：优秀毕业生
研究方向：植物抗逆及生殖发育以及铜离子在植物抗逆中的分子机制
文章： Liu Y, Zhang H, Li X, et al. (2018) : Quantitative trait locus mapping
for seed artificial aging traits using an F2:3 population and a recombinant inbred line
population crossed from two highly related maize inbreds. Plant Breeding. doi:10.1111/pbr.12663
姓名：刘文莉
职务：科研助理
教育背景：2016.9- 2020.5 烟台大学文经学院 生物工程 （本科）
2020.9-2023.6 烟台大学 分子生物学 （硕士）
研究方向：植物逆境胁迫响应的分子机制研究
文章：刘文莉,陈方军,杨博,等.藜麦NRT2基因家族鉴定及生物信息学分析[J].[2024-12-09].